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Article

Influence of UGT1A8 and UGT2B7 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients.

European journal of clinical pharmacology - 1 Mar 2007

Kagaya Hideaki, Inoue Kazuyuki, Miura Masatomo, Satoh Shigeru, Saito Mitsuru, Tada Hitoshi, Habuchi Tomonori, Suzuki Toshio

Abstract excerpt

OBJECTIVE: UGT1A8 and UGT2B7 are important uridine diphosphate-glucuronosyltransferase isoforms for the glucuronidation of mycophenolic acid (MPA). The aim of this investigation was to elucidate MPA pharmacokinetics in UGT1A8 and UGT2B7 genotypes in Japanese renal transplant recipients. METHODS: Seventy-two recipients received repeated doses of mycophenolate mofetil and tacrolimus. On day 28 after renal...

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PMID: 17211619
DOI: 10.1007/s00228-006-0248-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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