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Article

Influence of hepatic and intestinal efflux transporters and their genetic variants on the pharmacokinetics and pharmacodynamics of raloxifene in osteoporosis treatment.

Translational research : the journal of laboratory and clinical medicine - 1 Oct 2012

Trdan Lušin Tina, Mrhar Aleš, Stieger Bruno, Kullak-Ublick Gerd A, Marc Janja, Ostanek Barbara, Zavratnik Andrej, Kristl Albin, Berginc Katja, Delić Katja, Trontelj Jurij

Abstract excerpt

Raloxifene exhibits a large and unexplained interindividual variability in its pharmacokinetics and pharmacodynamics. The aim of our study was to identify transporters involved in the efflux of raloxifene and its glucuronide metabolites by various in vitro models and by an in vivo study to explore the possible involvement of P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP)1, MRP2, MRP3, and...

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Share to Bone Density Conservation Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22683417
DOI: 10.1016/j.trsl.2012.03.002

Genes

ABCB1
ABCC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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