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Article

Active metabolite concentration of clopidogrel in patients taking different doses of aspirin: results of the interaction trial.

Journal of thrombosis and haemostasis : JTH - 1 Mar 2015

Liang Y, Hirsh J, Weitz J I, Sloane D, Gao P, Pare G, Zhu J, Eikelboom J W

Abstract excerpt

BACKGROUND: The CURRENT-OASIS-7 and PLATO trials suggest that the benefit of clopidogrel is influenced by the dose of aspirin. OBJECTIVE: To explore a potential pharmacokinetic interaction between aspirin and clopidogrel, and determinants of clopidogrel active metabolite (AM) levels. METHODS: In part 1, using a 2 × 2 factorial design, we randomized patients to clopidogrel 600 mg loading dose (LD) followed by 150...

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Identifiers

PMID: 25557828
DOI: 10.1111/jth.12829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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