Article
Development of a physiology-directed population pharmacokinetic and pharmacodynamic model for characterizing the impact of genetic and demographic factors on clopidogrel response in healthy adults.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 20 Jan 2016
Jiang Xi-Ling, Samant Snehal, Lewis Joshua P, Horenstein Richard B, Shuldiner Alan R, Yerges-Armstrong Laura M, Peletier Lambertus A, Lesko Lawrence J, Schmidt Stephan
Abstract excerpt
Clopidogrel (Plavix®), is a widely used antiplatelet agent, which shows high inter-individual variability in treatment response in patients following the standard dosing regimen. In this study, a physiology-directed population pharmacokinetic/pharmacodynamic (PK/PD) model was developed based on clopidogrel and clopidogrel active metabolite (clop-AM) data from the PAPI and the PGXB2B studies using a step-wise...
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