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Article

Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone.

Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2016

Itkonen Matti K, Tornio Aleksi, Neuvonen Mikko, Neuvonen Pertti J, Niemi Mikko, Backman Janne T

Abstract excerpt

The glucose-lowering drug pioglitazone undergoes hepatic CYP2C8-mediated biotransformation to its main metabolites. The antiplatelet drug clopidogrel is metabolized to clopidogrel acyl-β-d-glucuronide, which was recently found to be a strong time-dependent inhibitor of CYP2C8 in humans. Therefore, we studied the effect of clopidogrel on the pharmacokinetics of pioglitazone. In a randomized crossover study, 10...

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Identifiers

PMID: 27260150
DOI: 10.1124/dmd.116.070375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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