Article
Frequency of immunohistochemical loss of mismatch repair protein in double primary cancers of the colorectum and stomach in Japan.
Diseases of the colon and rectum - 1 Oct 2006
Hayashi Tetsuji, Arai Masami, Ueno Masashi, Kinoshita Hirokatsu, Tada Yurika, Koizumi Koichi, Miki Yoshio, Yamaguchi Toshiharu, Kato Yo, Utsunomiya Joji, Muto Tetsuichiro, Sugihara Kenichi
Abstract excerpt
PURPOSE: Colorectal cancer and gastric cancer are the two most commonly associated malignancies in Japan. We examined mismatch repair deficiency in the tumors of patients with primary colorectal and gastric cancers retrospectively. METHODS: In 103 cases and 102 healthy control subjects, surgical specimens of colorectal and gastric cancer underwent immunohistochemical analysis of mismatch repair proteins (hMLH1...
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