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Article

Mismatch repair proteins immunohistochemical null phenotype in colon medullary carcinoma.

Clinical journal of gastroenterology - 1 Oct 2021

Tatsuta Kyota, Sakata Mayu, Iwaizumi Moriya, Shinmura Kazuya, Akai Toshiya, Kawamura Takafumi, Torii Kakeru, Morita Yoshifumi, Kikuchi Hirotoshi, Hiramatsu Yoshihiro, Fukazawa Atsuko, Kurachi Kiyotaka, Takeuchi Hiroya

Abstract excerpt

INTRODUCTION: In mismatch repair (MMR) immunohistochemistry, four MMR proteins' staining pattern reveals which particular gene may be defective. However, in the null phenotype, four MMR proteins are lost; consequently, it will be challenging to assume the target gene by immunohistochemistry and to determine whether deficient MMR was sporadic or germline. CASE REPORT: A 70-year-old man underwent right...

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PMID: 34279804
DOI: 10.1007/s12328-021-01484-6

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