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Article

Role of L2DTL, Cell Cycle-Regulated Nuclear and Centrosome Protein, in Aggressive HepatocellularCarcinoma

2 Nov 2006

Abstract excerpt

L2DTL is a human ortholog of Drosophila lethal (2) denticleless, l(2)dtl. This study is to elucidate its function and clinicopathological significance in hepatocellular carcinoma (HCC) progression. We used RT-PCR, immunostaining, Western blotting, and centrosome isolation to determine the L2DTL expression and protein localization, and RNAi to analyze its role in tumor cell growth. L2DTL protein located to the...

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PMID: 17106265
DOI: 10.4161/cc.5.22.3500

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