In vivo CRISPR screen identifies LTN1 as a novel tumor suppressor ubiquitinating insulin–like growth factor 2 mRNA–binding protein 1 in hepatocellular carcinoma

Abstract excerpt

BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is a frequent and aggressive kind of cancer. Although E3 ligases play important roles in HCC development, several E3 ligases remain unknown. APPROACH AND RESULTS: Through in vivo CRISPR knockout (KO) screens targeting related E3 ligase genes in HCC nude mice models, we discovered LTN1 as a novel tumor suppressor in HCC. Co-IP paired with 2D-LC-MS/MS and...

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