Article
Reagentless ultrasensitive specific DNA array detection based on responsive polymeric biochips.
Analytical chemistry - 15 Nov 2006
Najari Ahmed, Ho Hoang Anh, Gravel Jean-François, Nobert Philippe, Boudreau Denis, Leclerc Mario
Abstract excerpt
Self-assembled molecular structures immobilized on solid substrates and composed of fluorophore-tagged oligonucleotide probes and an optical polymeric transducer were investigated for the trace level detection of DNA target molecules. Rapid and efficient energy transfer between the polymeric transducer and fluorophores within the molecular aggregates leads to a massive intrinsic amplification of the fluorescence...
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