Article
Analysis of PTEN mutation in non-familial pheochromocytoma.
Annals of the New York Academy of Sciences - 1 Aug 2006
Puc Janusz, Placha Grzegorz, Wocial Bozenna, Podsypanina Katrina, Parsons Ramon, Gaciong Zbigniew
Abstract excerpt
PTEN, a tumor suppressor gene, is frequently mutated in a variety of human tumors. In mice, monoallelic inactivation of this gene predisposes animals to neoplasia of multiple organs. Interestingly, Pten heterozygous mice develop bilateral hyperplasia of the adrenal medulla. In this report we demonstrate that these neoplasms are hormonally active pheochromocytomas that secrete increased amounts of bioactive...
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