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Article

Conditional Inactivation of<i>Pten</i>with<i>EGFR</i>Overexpression in Schwann Cells Models Sporadic MPNST

1 Jan 2012

Abstract excerpt

The genetic mechanisms involved in the transformation from a benign neurofibroma to a malignant sarcoma in patients with neurofibromatosis-type-1- (NF1-)associated or sporadic malignant peripheral nerve sheath tumors (MPNSTs) remain unclear. It is hypothesized that many genetic changes are involved in transformation. Recently, it has been shown that both phosphatase and tensin homolog (PTEN) and epidermal growth...

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PMID: 23319880
DOI: 10.1155/2012/620834

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Conditional Inactivation of<i>Pten</i>with<i>EGFR</i>Overexpression in Schwann Cells Models Sporadic MPNSTPMID 23319880Read ↗

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