Article
Genetic alterations of the RET proto-oncogene in familial and sporadic pheochromocytomas.
Hormone research - 1 Jan 1997
Rodien P, Jeunemaitre X, Dumont C, Beldjord C, Plouin P F
Abstract excerpt
The identification of RET proto-oncogene mutations associated with multiple endocrine neoplasia type 2 (MEN-2) has provided a convenient screening test for MEN-2 in patients with pheochromocytoma (PH). In 120 patients with apparently sporadic PH, we analyzed RET exons 10, 11, 13 and 16 using dena...
Topics
- Adrenal Gland Neoplasms
- Adult
- DNA Mutational Analysis
- Drosophila Proteins
- Female
- Humans
- Male
- Middle Aged
- Multiple Endocrine Neoplasia Type 2a
- Mutation
- Pentagastrin
- Pheochromocytoma
- Proto-Oncogene Mas
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-ret
- Receptor Protein-Tyrosine Kinases