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Article

Genetic alterations of the RET proto-oncogene in familial and sporadic pheochromocytomas.

Hormone research - 1 Jan 1997

Rodien P, Jeunemaitre X, Dumont C, Beldjord C, Plouin P F

Abstract excerpt

The identification of RET proto-oncogene mutations associated with multiple endocrine neoplasia type 2 (MEN-2) has provided a convenient screening test for MEN-2 in patients with pheochromocytoma (PH). In 120 patients with apparently sporadic PH, we analyzed RET exons 10, 11, 13 and 16 using denaturing gradient gel electrophoresis and found a Leu to Phe missense mutation at codon 790 (exon 13) in 1 case. A TaqI...

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PMID: 9167962
DOI: 10.1159/000185474

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RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic alterations of the RET proto-oncogene in familial and sporadic pheochromocytomas.PMID 9167962Read ↗

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Tumor-specific mutations in the tyrosine kinase domain of the RET proto-oncogene in pheochromocytomas of sporadic type.Semantic proximity Read ↗

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Sporadic Pheochromocytomas Are Rarely Associated with Germline Mutations in the<i>vhl</i>Tumor Suppressor Gene or the<i>ret</i>Protooncogene<sup>1</sup>Semantic proximity Read ↗

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