Article
Missorting of the Aquaporin-2 mutant E258K to multivesicular bodies/lysosomes in dominant NDI is associated with its monoubiquitination and increased phosphorylation by PKC but is due to the loss of E258.
Pflugers Archiv : European journal of physiology - 1 Mar 2008
Kamsteeg Erik-Jan, Savelkoul Paul J M, Hendriks Giel, Konings Irene B M, Nivillac Nicole M I, Lagendijk Anne Karine, van der Sluijs Peter, Deen Peter M T
Abstract excerpt
To stimulate renal water reabsorption, vasopressin induces phosphorylation of Aquaporin-2 (AQP2) water channels at S256 and their redistribution from vesicles to the apical membrane, whereas vasopressin removal results in AQP2 ubiquitination at K270 and its internalization to multivesicular bodies (MVB). AQP2-E258K causes dominant nephrogenic diabetes insipidus (NDI), but its subcellular location is unclear, and...
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