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Article

Phenomic assessment of genetic buffering by kinetic analysis of cell arrays.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014

Rodgers John, Guo Jingyu, Hartman John L

Abstract excerpt

Quantitative high-throughput cell array phenotyping (Q-HTCP) is applied to the genomic collection of yeast gene deletion mutants for systematic, comprehensive assessment of the contribution of genes and gene combinations to any phenotype of interest (phenomic analysis). Interacting gene networks influence every phenotype. Genetic buffering refers to how gene interaction networks stabilize or destabilize a...

Topics

Cryopreservation
Gene Deletion
Gene Expression Regulation, Fungal
Gene Regulatory Networks
Genomics
High-Throughput Screening Assays
Phenotype
Tissue Array Analysis
Yeasts

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25213246
DOI: 10.1007/978-1-4939-1363-3_12
PMCID: PMC4920064

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