Article
Reactivities of serotyping monoclonal antibodies with culture-adapted human rotaviruses.
Journal of clinical microbiology - 1 Mar 1991
Ward R L, McNeal M M, Clemens J D, Sack D A, Rao M, Huda N, Green K Y, Kapikian A Z, Coulson B S, Bishop R F
Abstract excerpt
Rotaviruses collected in Bangladesh during 1985 to 1986 were culture adapted and used in a comparative serotyping study with three groups of monoclonal antibodies, all of which reacted with the major neutralization protein (VP7) of serotype 1, 2, 3, or 4. The goals were to determine which monoclonal antibodies most accurately predicted the serotype and why large variations in serotyping efficiencies have occurred...
Topics
- Antibodies, Monoclonal
- Antibody Specificity
- Antigens, Viral
- Child, Preschool
- Epitopes
- Humans
- Infant
- Mutation
- Rotavirus
- Sensitivity and Specificity
- Serotyping