Preparation and characterization of a neutralizing monoclonal antibody directed to VP4 of rotavirus strain K8 which has unique VP4 neutralization epitopes.

doi:10.1007/BF01316751

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Article

Preparation and characterization of a neutralizing monoclonal antibody directed to VP4 of rotavirus strain K8 which has unique VP4 neutralization epitopes.

Archives of virology - 1 Jan 1991

Kobayashi N, Taniguchi K, Urasawa T, Urasawa S

Abstract excerpt

For selecting the neutralizing monoclonal antibodies (N-MAbs) directed to VP4 of rotavirus strain K8, which has unique VP4 neutralization epitopes, we prepared several reassortant viruses by mixed infection of two different strains K8 (serotype 1) and P (serotype 3) in vitro: three reassortant clones having VP4 of K8 and VP7 of P and four clones having VP4 of P and VP7 of K8. By using these reassortants in...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antigens, Viral
Capsid
Capsid Proteins
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Epitopes
Female
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Molecular Sequence Data

Mutation

Neutralization Tests

RNA, Viral

Rotavirus

Sequence Alignment

Source

Open in PubMed

Identifiers

PMID: 1722090
DOI: 10.1007/BF01316751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1722090-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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