Article
Human rotavirus VP4 contains strain-specific, serotype-specific and cross-reactive neutralization sites.
Archives of virology - 1 Jan 1996
Kirkwood C D, Bishop R F, Coulson B S
Abstract excerpt
The neutralization epitopes of human rotavirus VP4 were studied by using a panel of neutralization monoclonal antibodies previously shown to be strain-specific (RV-3:3), serotype-specific (RV-5:2, ST-3:3) or cross-reactive (F45:4). Antigenic variants of human rotaviruses RV-3, ST-3, RV-5 and F45 resistant to neutralization by the appropriate of VP4 specific monoclonal antibodies (RV-3:3, ST-3:3, RV-5:2 and F45:4...
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