Article
Isolation of human monoclonal antibodies that neutralize human rotavirus.
Journal of virology - 1 Apr 2004
Higo-Moriguchi Kyoko, Akahori Yasushi, Iba Yoshitaka, Kurosawa Yoshikazu, Taniguchi Koki
Abstract excerpt
A human antibody library constructed by utilizing a phage display system was used for the isolation of human antibodies with neutralizing activity specific for human rotavirus. In the library, the Fab form of an antibody fused to truncated cp3 is expressed on the phage surface. Purified virions of strain KU (G1 serotype and P[8] genotype) were used as antigen. Twelve different clones were isolated. Based on their...
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