Article
Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins.
Virology - 30 Mar 2007
Kothe Denise L, Decker Julie M, Li Yingying, Weng Zhiping, Bibollet-Ruche Frederic, Zammit Kenneth P, Salazar Maria G, Chen Yalu, Salazar-Gonzalez Jesus F, Moldoveanu Zina, Mestecky Jiri, Gao Feng, Haynes Barton F, Shaw George M, Muldoon Mark, Korber Bette T M, Hahn Beatrice H
Abstract excerpt
"Centralized" (ancestral and consensus) HIV-1 envelope immunogens induce broadly cross-reactive T cell responses in laboratory animals; however, their potential to elicit cross-reactive neutralizing antibodies has not been fully explored. Here, we report the construction of a panel of consensus subtype B (ConB) envelopes and compare their biologic, antigenic, and immunogenic properties to those of two wild-type...
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