Joint effects of germ-line p53 mutation and sex on cancer risk in Li-Fraumeni syndrome.

Abstract excerpt

Germ-line p53 mutations have been identified in most families with Li-Fraumeni syndrome (LFS). For germ-line p53 mutation carriers, there is considerable variability with respect to age of cancer onset and tumor type, suggesting that additional genetic effects influence the clinical severity and tumor spectrum. To identify factors that might contribute to the observed heterogeneity in time to onset, we used...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adolescent
• Share to Family
• Share to Genes, p53