Article
Late appearance of glutamate transporter defects in a murine model of ALS-parkinsonism dementia complex.
Neurochemistry international - 1 Jun 2007
Wilson J M B, Shaw C A
Abstract excerpt
Excitotoxicity has been widely hypothesized to play a major role in various neurodegenerative diseases. We have used a mouse model of ALS-parkinsonism dementia complex (ALS-PDC) of the Western Pacific to explore this hypothesis. Mice fed washed cycad flour, the major epidemiological link to ALS-PDC, showed significant and progressive motor, cognitive, and sensory behavioural deficits [Wilson, J.M., Khabazian, I.,...
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