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Article

The bHLH transcription factor Hand is regulated by Alk in the Drosophila embryonic gut.

Biochemical and biophysical research communications - 29 Dec 2006

Varshney Gaurav K, Palmer Ruth H

Abstract excerpt

During embryonic development the midgut visceral muscle is formed by fusion of cells within the visceral mesoderm, a process initiated by the specification of a specialised cell type, the founder cell, within this tissue. Activation of the receptor tyrosine kinase Anaplastic lymphoma kinase (Alk) in the developing visceral muscle of Drosophila melanogaster initiates a signal transduction pathway required for...

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Identifiers

PMID: 17094947
DOI: 10.1016/j.bbrc.2006.10.117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The bHLH transcription factor Hand is regulated by Alk in the Drosophila embryonic gut.PMID 17094947Read ↗

Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.Semantic proximity Read ↗

The bHLH Transcription Factor Hand Regulates the Expression of Genes Critical to Heart and Muscle Function in Drosophila melanogaster.Semantic proximity Read ↗

Myoblast determination in the somatic and visceral mesoderm depends on Notch signalling as well as on milliways(mili(Alk)) as receptor for Jeb signalling.Semantic proximity Read ↗

The Drosophila Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis.Semantic proximity Read ↗

The scaffolding protein Cnk Interacts with Alk to Promote Visceral Founder Cell Specification in <i>Drosophila</i>Semantic proximity Read ↗

Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm.Semantic proximity Read ↗

An evolutionary shift in the regulation of the Hippo pathway between mice and flies.Semantic proximity Read ↗

Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function.Semantic proximity Read ↗

The Fused toes (Ft) mouse mutation causes anteroposterior and dorsoventral polydactyly.Semantic proximity Read ↗

<i>barx1</i> represses joints and promotes cartilage in the craniofacial skeletonSemantic proximity Read ↗

Cross-regulation of Hox genes in the Drosophila melanogaster embryo.Semantic proximity Read ↗

REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity.Semantic proximity Read ↗

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