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Article

Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.

Nature - 2 Oct 2003

Englund Camilla, Lorén Christina E, Grabbe Caroline, Varshney Gaurav K, Deleuil Fabienne, Hallberg Bengt, Palmer Ruth H

Abstract excerpt

The Drosophila melanogaster gene Anaplastic lymphoma kinase (Alk) is homologous to mammalian Alk, a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs). We have previously shown that the Drosophila Alk RTK is crucial for visceral mesoderm development during early embryogenesis. Notably, observed Alk visceral mesoderm defects are highly reminiscent of the phenotype reported for the secreted molecule...

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Source

Identifiers

PMID: 14523447
DOI: 10.1038/nature01950

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.PMID 14523447Read ↗

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Evolutionary analyses guide selection of model systems to investigate proto-oncogene function in ALK and LTKSemantic proximity Read ↗

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The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII.Semantic proximity Read ↗

Anaplastic lymphoma kinase: signalling in development and diseaseSemantic proximity Read ↗

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