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Article

Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl.

The FEBS journal - 1 Dec 2006

Sanjay Archana, Miyazaki Tsuyoshi, Itzstein Cecile, Purev Enkhtsetseg, Horne William C, Baron Roland

Abstract excerpt

Cbl is an adaptor protein and ubiquitin ligase that binds and is phosphorylated by the nonreceptor tyrosine kinase Src. We previously showed that the primary interaction between Src and Cbl is mediated by the Src homology domain 3 (SH3) of Src binding to proline-rich sequences of Cbl. The peptide Cbl RDLPPPPPPDRP(540-551), which corresponds to residues 540-551 of Cbl, inhibited the binding of a GST-Src SH3 fusion...

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Identifiers

PMID: 17094785
DOI: 10.1111/j.1742-4658.2006.05535.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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