Article
Phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse.
The Journal of biological chemistry - 29 Mar 2013
Sanbe Atsushi, Marunouchi Tetsuro, Abe Tsutomu, Tezuka Yu, Okada Mizuki, Aoki Sayuri, Tsumura Hideki, Yamauchi Junji, Tanonaka Kouichi, Nishigori Hideo, Tanoue Akito
Abstract excerpt
A K141N missense mutation in heat shock protein (HSP) B8, which belongs to the small HSP family, causes distal hereditary motor neuropathy, which is characterized by the formation of inclusion bodies in cells. Although the HSPB8 gene causes hereditary motor neuropathy, obvious expression of HSPB8 is also observed in other tissues, such as the heart. The effects of a single mutation in HSPB8 upon the heart were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.