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Article

Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart.

PLoS genetics - 1 Jan 2013

Melkani Girish C, Trujillo Adriana S, Ramos Raul, Bodmer Rolf, Bernstein Sanford I, Ocorr Karen

Abstract excerpt

Amyloid-like inclusions have been associated with Huntington's disease (HD), which is caused by expanded polyglutamine repeats in the Huntingtin protein. HD patients exhibit a high incidence of cardiovascular events, presumably as a result of accumulation of toxic amyloid-like inclusions. We have generated a Drosophila model of cardiac amyloidosis that exhibits accumulation of PolyQ aggregates and oxidative...

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PMID: 24367279
DOI: 10.1371/journal.pgen.1004024
PMCID: PMC3868535

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