Article
CD8+CD28- regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice.
Gastroenterology - 1 Dec 2006
Ménager-Marcq Ingrid, Pomié Céline, Romagnoli Paola, van Meerwijk Joost P M
Abstract excerpt
BACKGROUND & AIMS: Immune responses to innocuous intestinal antigens appear tightly controlled by regulatory T lymphocytes. While CD4+ T lymphocytes have recently attracted the most attention, CD8+ regulatory T-cell populations are also believed to play an important role in control of mucosal immunity. However, CD8+ regulatory T-cell function has mainly been studied in vitro and no direct in vivo evidence exists...
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