Article
Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.
Science (New York, N.Y.) - 2 Apr 1999
Soengas M S, Alarcón R M, Yoshida H, Giaccia A J, Hakem R, Mak T W, Lowe S W
Abstract excerpt
The ability of p53 to promote apoptosis in response to mitogenic oncogenes appears to be critical for its tumor suppressor function. Caspase-9 and its cofactor Apaf-1 were found to be essential downstream components of p53 in Myc-induced apoptosis. Like p53 null cells, mouse embryo fibroblast cells deficient in Apaf-1 and caspase-9, and expressing c-Myc, were resistant to apoptotic stimuli that mimic conditions...
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