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Article

Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment.

Cancer letters - 1 Feb 2013

Jin Linhua, Tabe Yoko, Lu Hongbo, Borthakur Gautam, Miida Takashi, Kantarjian Hagop, Andreeff Michael, Konopleva Marina

Abstract excerpt

We investigated the antileukemia effects and molecular mechanisms of apoptosis induction by simultaneous blockade of PI3K and mutant FLT3 in AML cells grown under hypoxia in co-cultures with bone marrow stromal cells. Combined treatment with selective class I PI3K inhibitor GDC-0941 and sorafenib reversed the protective effects of bone marrow stromal cells on FLT3-mutant AML cells in hypoxia, which was associated...

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Source

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Identifiers

PMID: 23036488
DOI: 10.1016/j.canlet.2012.09.020
PMCID: PMC3572533

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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