Article
Single nucleotide polymorphism of the human kallikrein-2 gene highly correlates with serum human kallikrein-2 levels and in combination enhances prostate cancer detection.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Jun 2003
Nam Robert K, Zhang William W, Trachtenberg John, Diamandis Eleftherios, Toi Ants, Emami Marjan, Ho Minnie, Sweet Joan, Evans Andrew, Jewett Michael A S, Narod Steven A
Abstract excerpt
PURPOSE: We examined the relationship between a mutant (T) for wild-type (C) allele substitution of the human kallikrein-2 gene (KLK2), circulating human kallikrein-2 (hK2) levels and prostate cancer risk. PATIENTS AND METHODS: We studied 1,287 consecutive men who underwent prostate biopsies because of an abnormal prostate-specific antigen level. Serum and DNA were obtained before biopsy. Cases were patients with...
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