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Article

Evidence that less-than-full-length pol gene products are functional in hepadnavirus DNA synthesis.

Journal of virology - 1 May 1991

Wu T T, Condreay L D, Coates L, Aldrich C, Mason W

Abstract excerpt

Duck hepatitis B virus mutants containing frameshift or stop codon mutations in a portion of the viral pol gene separating the terminal protein and reverse transcriptase domains had a leaky phenotype and, depending on the location and type of mutation, synthesized up to 10% as much viral DNA as d...

Topics

Base Sequence
Cells, Cultured
Codon
DNA, Viral
Frameshift Mutation
Gene Products, pol
Genes, pol
Genetic Complementation Test
Hepatitis B Virus, Duck
Humans
Molecular Sequence Data
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Biosynthesis

RNA-Directed DNA Polymerase

Recombinant Fusion Proteins

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1707980
DOI: 10.1128/JVI.65.5.2155-2163.1991
PMCID: PMC240562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1707980-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Evidence that less-than-full-length pol gene products are functional in hepadnavirus DNA synthesis.PMID 1707980Read ↗

Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymeraseSemantic proximity Read ↗

Mutational analysis of the hepatitis B virus P gene product: domain structure and RNase H activity.Semantic proximity Read ↗

Selected mutations of the duck hepatitis B virus P gene RNase H domain affect both RNA packaging and priming of minus-strand DNA synthesisSemantic proximity Read ↗

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Effects of mutations within and adjacent to the terminal repeats of hepatitis B virus pregenomic RNA on viral DNA synthesis.Semantic proximity Read ↗

Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication.Semantic proximity Read ↗

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A short cis-acting sequence is required for hepatitis B virus pregenome encapsidation and sufficient for packaging of foreign RNA.Semantic proximity Read ↗

Synthesis of hepadnavirus particles that contain replication-defective duck hepatitis B virus genomes in cultured HuH7 cells.Semantic proximity Read ↗

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Characterization of the pleiotropic effects of the genotype G-specific 36-nucleotide insertion in the context of other hepatitis B virus genotypes.Semantic proximity Read ↗

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