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Article

Bchs, a BEACH domain protein, antagonizes Rab11 in synapse morphogenesis and other developmental events.

Development (Cambridge, England) - 1 Dec 2006

Khodosh Rita, Augsburger Adela, Schwarz Thomas L, Garrity Paul A

Abstract excerpt

BEACH proteins, an evolutionarily conserved family characterized by the presence of a BEACH (Beige and Chédiak-Higashi) domain, have been implicated in membrane trafficking, but how they interact with the membrane trafficking machinery is unknown. Here we show that the Drosophila BEACH protein Bchs (Blue cheese) acts during development as an antagonist of Rab11, a small GTPase involved in vesicle trafficking. We...

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PMID: 17079274
DOI: 10.1242/dev.02650

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