Article
Increased polymorphism in the HR-1 gp41 env gene encoding the enfuvirtide (T-20) target in HIV-1 variants harboring multiple antiretroviral drug resistance mutations in the pol gene.
Journal of acquired immune deficiency syndromes (1999) - 1 Jan 2007
Si-Mohamed Ali, Piketty Christophe, Tisserand Pascaline, LeGoff Jérôme, Weiss Laurence, Charpentier Charlotte, Kazatchkine Michel D, Bélec Laurent
Abstract excerpt
BACKGROUND: Sequence variations in HR-1 gp41 env gene region encoding the target for T-20 have previously been reported among patients naive to inhibitory fusion. OBJECTIVE: To evaluate whether a previous therapeutic history of patients could have an impact on a differential evolution of the gp41...
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