Article
Characterization of genotypic determinants in HR-1 and HR-2 gp41 domains in individuals with persistent HIV viraemia under T-20.
AIDS (London, England) - 18 Jun 2004
Marcelin Anne-Geneviève, Reynes Jacques, Yerly Sabine, Ktorza Nadine, Segondy Michel, Piot Jean-Claude, Delfraissy Jean-François, Kaiser Laurent, Perrin Luc, Katlama Christine, Calvez Vincent
Abstract excerpt
We analysed the genetic changes in gp41 in a population of 30 heavily pretreated HIV-1-infected patients failing on a T-20-containing salvage therapy. This study confirms the key role of the number of drugs presumed to be still effective associated with T-20 in the magnitude of the virological response. Our results suggest that only HR-1 sequencing is necessary to characterize resistance to T-20, and that HR-2...
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