Article
ADRB2 polymorphisms and asthma susceptibility: transmission disequilibrium test and meta-analysis.
International archives of allergy and immunology - 1 Jun 2004
Migita Ohsuke, Noguchi Emiko, Jian Zhang, Shibasaki Masanao, Migita Takuo, Ichikawa Kunio, Matsui Akira, Arinami Tadao
Abstract excerpt
BACKGROUND: The beta(2)-adrenergic receptor (ADRB2) is the most common adrenergic receptor in the lung, and associations between ADRB2 polymorphisms and intermediate phenotypes of asthma have been reported. Four missense polymorphisms (Arg16Gly, Gln27Glu, Val34Met, and Thr164Ile) and one polymorphism in the 5' leader cistron of the ADRB2 messenger RNA has been identified. In vitro studies have shown that these...
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