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Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector

1 Jan 1992

Abstract excerpt

A defective adenovirus (Ad) type 5 E1- vector has been combined with the powerful constitutive cytomegalovirus (CMV) major immediate early (IE) promoter to produce a novel eukaryotic expression system. The Ad vector can replicate to high titres in 293 cells and then be used to infect a wide variety of non-permissive cell types. The Escherichia coli lacZ and CMV IE1 genes have been cloned to generate the Ad...

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PMID: 1317548
DOI: 10.1093/nar/20.9.2233

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