Article
[Serotonin transporter gene polymorphisms in irritable bowel syndrome and their impact on tegaserod treatment].
Zhonghua nei ke za zhi - 1 Jul 2006
Li Yu-yuan, Nie Yu-qiang, Xie Jun, Tan Hui-zhen, Zhou Yong-jian, Wang Hong
Abstract excerpt
OBJECTIVE: To investigate the serotonin reuptake transporter (SERT) genetic polymorphisms in the 5-hydroxytryptamine (5-HT) transporter gene-linked polymorphic region (5-HTTLPR) and the variable number tandem repeats (VNTRs) in intron 2 among Chinese people, and their relationship to the pathogenesis of irritable bowel syndrome (IBS); and to investigate the impact of SERT genotypes on the efficacy of 5-HT(4)...
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