Article
A novel missense mutation C11994T in the mitochondrial ND4 gene as a cause of low sperm motility in the Indian subcontinent.
Fertility and sterility - 1 Dec 2006
Selvi Rani Deepa, Vanniarajan Ayyasamy, Gupta Nalini J, Chakravarty Baidyanath, Singh Lalji, Thangaraj Kumarasamy
Abstract excerpt
We have analyzed the mitochondrial DNA of 34 oligoasthenozoospermic men along with 150 normozoospermic fertile men from the Indian subcontinent. A novel missense mutation (C11994T) in the ND4 gene, which replaces threonine with isoleucine, was observed in all of the oligoasthenozoospermic men but not in any of the normozoospermic fertile men.
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