Article
High incidence of single nucleotide substitutions in the mitochondrial genome is associated with poor semen parameters in men.
International journal of andrology - 1 Jun 2001
Holyoake A J, McHugh P, Wu M, O'Carroll S, Benny P, Sin I L, Sin F Y
Abstract excerpt
Single nucleotide polymorphisms (SNPs) in 7000 bp of the mitochondrial genome, encompassing 15 coding regions from COI to ND5, were characterized by single strand polymorphism analysis and confirmed by DNA sequencing. About 2.4% of normozoospermic men and 8.4% of men with poor semen quality had at least one nucleotide substitution. Most of the substitutions occurred in the third codon and did not change the amino...
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