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A genome-wide association study of mitochondrial DNA in Chinese men identifies two risk single nucleotide substitutions for idiopathic oligoasthenospermia.

Mitochondrion - 1 Sept 2015

Lu Chuncheng, Xu Miaofei, Wang Rong, Qin Yufeng, Ren Jing, Wu Wei, Song Ling, Wang Shoulin, Zhou Zuomin, Shen Hongbing, Sha Jiahao, Hu Zhibin, Xia Yankai, Miao Dengshun, Wang Xinru

Abstract excerpt

Mitochondrial DNA (mtDNA) is believed to be both the source and target of reactive oxygen species (ROS), and mtDNA genetic alterations have been reported to be associated with molecular defects in the oxidative phosphorylation (OXPHOS) system. In order to investigate the potentially susceptible mtDNA genetic variants to oligoasthenospermia, we conducted a two-stage study in 921 idiopathic infertile men with...

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Identifiers

PMID: 26231857
DOI: 10.1016/j.mito.2015.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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