Article
Chondrogenic differentiation alters the immunosuppressive property of bone marrow-derived mesenchymal stem cells, and the effect is partially due to the upregulated expression of B7 molecules.
Stem cells (Dayton, Ohio) - 1 Feb 2007
Chen Xi, McClurg Angela, Zhou Guang-Qian, McCaigue Mervyn, Armstrong Marilyn Ann, Li Gang
Abstract excerpt
To investigate the immunosuppressive properties of MSCs, in the present study we examined the immunogenicity of undifferentiated and trilineage-differentiated (chondrocytes, osteoblasts, and adipocytes) rat bone marrow-derived MSCs under xenogeneic conditions. After chondrogenic differentiation, rat bone marrow-derived MSCs stimulated human dendritic cells (hDCs) derived from peripheral blood monocytes, leading...
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