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Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells

29 Sept 2011

Abstract excerpt

Dendritic cells (DC) are highly specialized antigen-presenting cells characterized by the ability to prime T-cell responses. Mesenchymal stem cells (MSC) are adult stromal progenitor cells displaying immunomodulatory activities including inhibition of DC maturation in vitro. However, the specific impact of MSC on DC functions, upon in vivo administration, has never been elucidated. Here we show that murine MSC...

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PMID: 21960443
DOI: 10.1073/pnas.1103650108

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