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Article

Hypermethylated RASSF1A in maternal plasma: A universal fetal DNA marker that improves the reliability of noninvasive prenatal diagnosis.

Clinical chemistry - 1 Dec 2006

Chan K C Allen, Ding Chunming, Gerovassili Ageliki, Yeung Sze W, Chiu Rossa W K, Leung Tse N, Lau Tze K, Chim Stephen S C, Chung Grace T Y, Nicolaides Kypros H, Lo Y M Dennis

Abstract excerpt

BACKGROUND: We recently demonstrated that the promoter of the RASSF1A gene is hypermethylated in the placenta and hypomethylated in maternal blood cells. This methylation pattern allows the use of methylation-sensitive restriction enzyme digestion for detecting the placental-derived hypermethylat...

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Identifiers

PMID: 17068167
DOI: 10.1373/clinchem.2006.074997

Genes

RHD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17068167-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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