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Article

Mrassf1a-pap, a novel methylation-based assay for the detection of cell-free fetal DNA in maternal plasma.

PloS one - 1 Jan 2013

van den Oever Jessica M E, Balkassmi Sahila, Segboer Tim, Verweij E Joanne, van der Velden Pieter A, Oepkes Dick, Bakker Egbert, Boon Elles M J

Abstract excerpt

OBJECTIVES: RASSF1A has been described to be differentially methylated between fetal and maternal DNA and can therefore be used as a universal sex-independent marker to confirm the presence of fetal sequences in maternal plasma. However, this requires highly sensitive methods. We have previously shown that Pyrophosphorolysis-activated Polymerization (PAP) is a highly sensitive technique that can be used in...

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PMID: 24391879
DOI: 10.1371/journal.pone.0084051
PMCID: PMC3877162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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