Transcription factor‐mediated molecular mechanisms involved in the functional cross‐talk between cytokines and glucocorticoids

Abstract excerpt

After antigenic stimulation the increase in cytokine levels constitutes a fundamental event in the host defense and mediates many processes such as inflammation, B- and T-cell growth and differentiation and activation of effector cells. Most of these processes depend on the cytokine-induced activation of transcription factors that modulate the expression of target genes. Cytokines induce a rise in glucocorticoid...

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