Article
Neurotoxicity of lidocaine involves specific activation of the p38 mitogen-activated protein kinase, but not extracellular signal-regulated or c-jun N-terminal kinases, and is mediated by arachidonic acid metabolites.
Anesthesiology - 1 Nov 2006
Haller Ingrid, Hausott Barbara, Tomaselli Bettina, Keller Christian, Klimaschewski Lars, Gerner Peter, Lirk Philipp
Abstract excerpt
BACKGROUND: Pharmacologic inhibition of the p38 mitogen-activated protein kinase (MAPK) leads to a reduction in lidocaine neurotoxicity in vitro and in vivo. The current study investigated in vitro the hypotheses that lidocaine neurotoxicity is specific for dorsal root ganglion cells of different...
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