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Article

In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity.

Anesthesia and analgesia - 1 May 2008

Lirk Philipp, Haller Ingrid, Colvin Hans Peter, Lang Leopold, Tomaselli Bettina, Klimaschewski Lars, Gerner Peter

Abstract excerpt

BACKGROUND: Animal models show us that specific activation of the p38 mitogen-activated protein kinase (MAPK) may be a pivotal step in lidocaine neurotoxicity, but this has not been investigated in the case of two very widely used local anesthetics, bupivacaine and ropivacaine. We investigated the hypotheses that these drugs (A) are less neurotoxic than the prototype local anesthetic, lidocaine (B) are...

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Identifiers

PMID: 18420860
DOI: 10.1213/ane.0b013e318168514b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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