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Article

Histopathological features of breast cancer in carriers of ATM gene variants.

Histopathology - 1 Nov 2006

Balleine R L, Murali R, Bilous A M, Farshid G, Waring P, Provan P, Byth K, Thorne H, Kirk J A

Abstract excerpt

AIMS: Germline variants in the ataxia telangiectasia mutated (ATM) gene have been implicated in increased breast cancer risk. The aim of this study was to determine whether the histopathology of breast cancers occurring in ATM variant carriers is distinctive or resembles the described BRCA1 mutation-associated phenotype. METHODS: The histopathological features of breast cancers occurring in ATM variant carriers...

Topics

Adult
Aged
Ataxia Telangiectasia Mutated Proteins
Biomarkers, Tumor
Breast Neoplasms
Carcinoma, Ductal, Breast
Carcinoma, Intraductal, Noninfiltrating
Cell Cycle Proteins
Cohort Studies
DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Genes, BRCA1

Genes, BRCA2

Genetic Carrier Screening

Genetic Predisposition to Disease

Germ-Line Mutation

Humans

Middle Aged

Source

Identifiers

PMID: 17064299
DOI: 10.1111/j.1365-2559.2006.02538.x

Genes

ATM
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17064299-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Histopathological features of breast cancer in carriers of ATM gene variants.PMID 17064299Read ↗

Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers.Semantic proximity Read ↗

Invasive breast carcinomas with ATM gene variants of uncertain significance share distinct histopathologic features.Semantic proximity Read ↗

The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers.Semantic proximity Read ↗

Ataxia-telangiectasia gene (ATM) mutation heterozygosity in breast cancer: a narrative review.Semantic proximity Read ↗

Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history.Semantic proximity Read ↗

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Rare variants in the ATM gene and risk of breast cancer.Semantic proximity Read ↗

ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles.Semantic proximity Read ↗

Screening for ATM sequence alterations in African-American women diagnosed with breast cancer.Semantic proximity Read ↗

Histopathology of BRCA1- and BRCA2-associated breast cancer.Semantic proximity Read ↗

Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer.Semantic proximity Read ↗

The Ataxia-telangiectasia mutated gene and breast cancer: gene expression profiles and sequence variants.Semantic proximity Read ↗

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