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Article

IL-10/Janus kinase/signal transducer and activator of transcription 3 signaling dysregulates Bim expression in autoimmune lymphoproliferative syndrome.

The Journal of allergy and clinical immunology - 1 Mar 2015

Niss Omar, Sholl Allyson, Bleesing Jack J, Hildeman David A

Abstract excerpt

BACKGROUND: Autoimmune lymphoproliferative syndrome (ALPS) is a human disorder of T cell homeostasis caused by mutations that impair FAS-mediated apoptosis. A defining characteristic of ALPS is the expansion of double negative T cells (DNTC). Relatively little is known about how defective FAS-dri...

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Source

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Identifiers

PMID: 25174872
DOI: 10.1016/j.jaci.2014.07.020
PMCID: PMC4344440

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25174872-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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